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Lock solution Citralock

Lock solution for dialysis catheter

Citra-Lock™ - catheter lock solution, anti-clotting and antimicrobial is one of the innovations from Dirinco.


Citrate binds to calcium:

It is known that the construction of the biofilm is dependent on Calcium and Magnesium. Citra-LockTM is a strong chelator of both Mg2+ and Ca2+ leading to a decreased biofilm formation in catheters filled with Citra-LockTM and in this way preventing the catheter of related infections.


Citra-lock™ causes anticoagulation by chelation of ionised calcium in the extracorpereal circuit into a soluble complex. Because calcium is an integralion involved in the clotting cascade, local removal by Citra-Lock™ prevents the activation of clotting factors, factor X, and prothrombin, and the ultimate formation of fibrin. Systematic anticoagulation does not occur.

1. Ash SR (2000) Concentrated Sodium Citrate (23%) for Catheter Lock. Haemodialysis International 4:22-31

Anti microbial

Citra-Lock™ the Safe and Superior catheter lock solution.

The greatest significant decrease in incidence of symptomatic bacteraemia appears 
to occur with the use of 47% Citra-Lock1.

It prevents formation of biofilm in the catheter lumen, by eliminating the growth of 
bacteria, yeast and fungi which would normally form the biofilm.

1. Ash SR (2000) Concentrated Sodium Citrate (23%) for Catheter Lock. Haemodialysis International 4:22-31

Superior Antimicrobial Activity of Citra-Lock™ over Heparin

On all microbial strains heparin didn't show any inhibitory effect at all. Citra-Lock™ 30% and Citra-Lock™ 46,7% demonstrated an inhibitory effect on all the strains. Both concentrations of Citra-Lock also inhibit growth of C. albicans.

Agar diffusion susceptibility test. BA plates seeded with S. Aureus and wells filled with heparin (left), Citra-LockTM 30% ( middle) and Citra-Lock™ 46,7% ( right) after 24 hours at 37ºC showing large zone of bacterial killing for the citrate solutions.

2. VU Amsterdam(2005), Agar diffusion usceptibility test for heparine, Cita-Lock™ 30% and Citra-Lock™ 46,7%, Microbiological lab VU Amsterdam



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Reference Designation
Citralock 4 Citra-Lock™ 4% Needle Free Vial 5ml
Citralock 30 Citra-Lock™ 30% Needle Free Vial 5ml
Citralock 46,7 Citra-Lock™ 46,7% Needle Free Vial 5ml
Citralock-S 4 Citra-Lock™S 4%  2.5 ml sterile pre-filled syringe
Citralock-S 30 Citra-Lock™S 30%  2.5 ml sterile pre-filled syringe
Citralock-S 46,7 Citra-Lock™S 46,7%  2.5 ml sterile pre-filled syringe

Increase Safety & Simplicity

The new Citra-Lock™ vials: Drip free and with Luer connector

  • preventing microbial contamination

  • protecting against needle stick injuries

  • reducing handling steps

  • promoting intuitive handling



Lok CE, Appleton D, Bhola C, Khoo B, Richardson RM. Trisodium citrate 4%-an alternative to heparin capping of haemodialysis catheter. Nephrol Dial Transplant. 2006 Oct.

Grudzinski L et al. Sodium Citrate 4% locking solution for central veinous dialysis catheters – an effective, more cost efficient alternative to heparin. NDT Advance Access published October 25, 2006 Nephrol. Dial. Transplant doi:10/1093/ndt/gfl606.

Lok CE, Appleton D, Bhola C, Richardson RMA, et al. Trisodium citrate 4% : A less costly yet effective alternative to heparin capping of haemodialysis catheters. J.Am.Soc.Nephrol(Nov) 16:452A 2005

Michaud D, Komant T, Pfefferle P. Four percent trisodium citrate as an alternative anticoagulant for maintaining patency of central venous hemodialysis catheters : case, report and discussion. Am J Crit Care 2001;10:351-354

Buturovic J, Ponikvar R, Kandus A, Boh M, Klinkmann J, Ivanovich. Filling hemodialysis catheters in the interdialytic period : heparin vs citrate versus polygeline : a prospective randomized study. Artiff Organs 1998;22:945-947

Bayes B, Bonal J, Romero R. Sodium citrate for filling haemodialysis catheters. Nephrol Dial Transplant 1999; 14:2532-2533

Hendrickx L, Kuypers D, Evenepoel P, Maes B, Messiaen T, Vanrenterghem Y. A comparative prospective study on the use of low concentrate citrate lock versus heparin lock in permanent dialysis catheter. Int J Artif Organs 2001; 24:208-211

Flanigan MJ, Pillsbury L, Saderwasser G, Lim VS. Regional hemodialysis anticoagulant : Hypertonic tri-sodium citrate or anticoagulant citrate dextrose-A. Am J Kidney Dis 1996; 27:519-524

Meeus G, Kuypers DR, Claes K, Evenepoel P, Maes B, Vanrenterghem Y. A prospective, randomized, double-blind crossover study on the use of 5% citrate lock versus 10% citrate lock in permanent hemodialysis catheters. Blood Purif 2005;23:101-105.

Food and Drug Administration. FDA issues warning on Tricitrasol dialysis catheter anticoagulant. FDA.

Humber River Regional Hospital retrospective analysis to evaluate clinical experience with the use of sodium citrate 4% versus heparin 10,000 u/ml to maintain long term interdialytic patency of central venous hemodialysis catheter. (available upon request)

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